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目的 研究端粒酶活性表达在卵巢肿瘤诊断和鉴别诊断方面的意义。方法 应用原位杂交检测4 0例卵巢浆液性肿瘤组织 (良性组织 2 0例 ,交界性肿瘤 5例 ,恶性肿瘤 15例 )的端粒酶TERT蛋白表达状况。结果 2 0例卵巢良性组织中测出端粒酶TERT表达 1例 ,占 5 % ,5例交界性肿瘤组织中 ,3例 (6 0 % )TERT蛋白呈阳性表达 ,15例恶性肿瘤组织中 ,14例 (93.3% )TERT蛋白呈阳性表达。结论 端粒酶TERT蛋白表达的检测有助于卵巢肿瘤性质的诊断和鉴别诊断。
Objective To study the significance of telomerase activity in the diagnosis and differential diagnosis of ovarian tumors. Methods The expression of telomerase TERT protein in 40 cases of ovarian serous tumor tissue (20 cases of benign tissue, 5 cases of borderline tumor and 15 cases of malignant tumor) was detected by in situ hybridization. Results TERT expression was detected in 20 cases of benign ovarian tissues in 1 case, accounting for 5%. In 5 cases of borderline tumor tissues, 3 cases (60%) had positive TERT protein expression. In 15 cases of malignant tumors, TERT protein was positive in 14 cases (93.3%). Conclusion The detection of telomerase TERT protein contributes to the diagnosis and differential diagnosis of ovarian tumor.