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目前,治疗动脉导管未闭(PDA)仍采用消炎痛或外科手术。类固醇或许能通过干扰前列腺素的合成,或降低导管肌肉对前列腺素E_2的敏感性,而使PDA闭合。现将加拿大多伦多市妇科医院4例PDA患儿用地塞米松治疗情况报道如下。病例4例患儿均为23～26周胎龄的早产女婴,体重为550～805g。其中3例因新生儿呼吸窘迫综合征(RDS)、1例因初生时复苏而用呼吸机治疗。因有PDA用消炎痛曾使PDA闭合。此后,心脏听诊又有杂音,X光照片1～3例合并有支气管肺发育不
At present, the treatment of patent ductus arteriosus (PDA) is still used indomethacin or surgery. Steroids may close the PDA by interfering with the synthesis of prostaglandins or decreasing the sensitivity of the catheter muscles to prostaglandin E_2. Now Toronto City, Toronto Women’s Hospital 4 cases of dexamethasone treatment of PDA are reported below. Four cases of children with gestational age were 23 to 26 weeks gestational age premature baby girl weighing 550 ~ 805g. Three of them were diagnosed as neonatal respiratory distress syndrome (RDS), and one of them was treated with ventilator due to the recovery at birth. Because PDA with indomethacin PDA closed. Since then, heart auscultation and murmur, X-ray 1 to 3 cases with bronchopulmonary development is not