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近年来一系列研究提示,癌症与炎症细胞和介质之间有着密切关系,这为抗癌和抗炎新药研究开辟了新的途径。 一、肿瘤和巨噬细胞 免疫治疗和生物治疗恶性肿瘤已成为基础和临床研究中的重要课题。“免疫监管”的概念使人们相信,免疫反应对恶性肿瘤是一种重要的防御机制。令人瞩目的是淋巴细胞和巨噬细胞是机体抵抗肿瘤,尤其是转移性肿瘤的重要效应细胞。在肿瘤组织周围或组织内有吞噬细胞浸润,并出现炎症反应。激活的巨噬细胞能杀伤不同表现型的肿瘤细胞。肿瘤细胞增长时可分泌一种减弱淋巴细胞和巨噬细胞
In recent years, a series of studies have shown that there is a close relationship between cancer and inflammatory cells and media, which opens up new avenues for the research on new anti-cancer and anti-inflammatory drugs. First, tumor and macrophage immune therapy and biological treatment of malignant tumors has become an important issue in basic and clinical research. The concept of “immune regulation” leads people to believe that the immune response is an important defense mechanism for malignancies. What is remarkable is that lymphocytes and macrophages are important effector cells that the body resists tumors, especially metastatic tumors. There are phagocytic infiltration around the tumor tissue or tissue and inflammation. Activated macrophages can kill tumor cells of different phenotypes. Tumor cells can secrete a kind of weakened lymphocytes and macrophages when they grow