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应用免疫组织化学SP法检测Survivin蛋白在43例宫颈癌组织标本、20例宫颈原位癌、20例正常宫颈组织标本中的表达情况。结果Survivin蛋白阳性表达率宫颈癌组织显著高于正常宫颈组织(P<0.01),高于宫颈原位癌组织(P<0.05);有淋巴结转移者显著高于无淋巴转移者(P<0.05);病理分期为Ⅰ期者显著低于Ⅱ期者(P<0.05);随临床分期增加及淋巴结转移Survivin蛋白阳性表达率逐渐升高。提示Survivin在宫颈癌中的高表达与淋巴结转移及临床病理分期密切相关;Survivin可能是影响宫颈癌预后的重要指标。
Immunohistochemical SP method was used to detect the expression of Survivin protein in 43 cases of cervical cancer tissue, 20 cases of cervical carcinoma in situ and 20 cases of normal cervical tissue. Results The positive rate of Survivin expression in cervical cancer was significantly higher than that in normal cervical tissue (P <0.01), higher than that in cervical carcinoma (P <0.05). The positive rates of Survivin protein in cervical cancer were significantly higher than those without lymph node metastasis (P <0.05) (P <0.05). The positive rate of Survivin protein increased with the increase of clinical stage and lymph node metastasis. It is suggested that the high expression of Survivin in cervical cancer is closely related to lymph node metastasis and clinicopathological stage. Survivin may be an important indicator of the prognosis of cervical cancer.