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苯二甲酸酯类已广泛用作工业溶剂,以及多种塑料的增塑剂。如苯二甲酸二乙己酯[DEHP, di-(2-ethylhexyl) phathalate]是最常见的聚氯乙烯塑料的增塑剂。现已查明,多种海生生物、土壤、动物及人类的组织中广泛存在着DEHP。由于使用各种聚氯乙烯生物医学器械制品(如输液器具及透析管等),因此DEHP侵入血液,损害人体健康。曾有报告,DEHP可引起大鼠肝脏肿大及睾丸萎缩。本文作者进一步做了非啮齿类(海貂)动物毒性实验,证实DEHP对肝脏具有毒性。实验动物为18月令雄性海貂,体呕1,150～1,850g,喂饲含1%(W/W)DEHP的饲料14个月,平均摄入1,200mg/kg/日。受试动物肝脏匀浆的各种生化测定结果见附表。DEHP处理动物的肝脏绝对重量
Phthalates have been widely used as industrial solvents, as well as a variety of plastics plasticizers. Such as DEHP, di- (2-ethylhexyl) phathalate] is the most common PVC plasticizer. It has been identified that DEHP is widespread in a variety of marine, soil, animal and human tissues. Due to the use of a variety of polyvinyl chloride biomedical devices (such as infusion sets and dialysis tubing, etc.) DEHP invades the blood and damages human health. It has been reported that DEHP can cause rat liver enlargement and testicular atrophy. The author further made a non-rodent (sea mink) animal toxicity test, confirmed that DEHP is toxic to the liver. The experimental animals were male sea ferrets aged 18 months, and received 1,150-1,850 g of body weight vomit for 14 months with a feed containing 1% (w / w) DEHP with an average intake of 1,200 mg / kg / day. Various animal biochemical results of liver homogenate test results see attached. DEHP treated animals with absolute liver weight