系统性红斑狼疮和干燥综合征重叠患者出现多发性皮肤纤维瘤

• 作 者: Tsunemi Y. Tada Y. 马慧群
• 机 构: Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 1
• 出 处: 世界核心医学期刊文摘(皮肤病学分册)
• 发表日期: 2005年02期
• 关键词: 皮肤纤维瘤 系统性红斑狼疮 干燥综合征 自身免疫性疾病 报道提示 日本女性 病理发现 免疫抑制 免疫抑制治疗 免疫系统

Multiple dermatofibromas (DFs) are rare and have been thought to be associated with altered immunity. In this report, we describe a 27-year-old Japanese woman with systemic lupus erythematosus (SLE) and Sjgren’s syndrome in whom eight nodules appeared over a period of 4 years. Histopathological findings were consistent with DF. SLE rather than Sjgren’s syndrome seemed to have induced the multiple DFs in this patient. We also reviewed the reported cases with multiple DFs associated with SLE and/or Sjgren’s syndrome. Review of the previous reports indicates that SLE is the most frequent autoimmune disorder associated with multiple DFs, and that both SLE and immunosuppressive treatments play a part in induction of multiple DFs. Therefore, if multiple DFs are present it is important that the status of the patient be evaluated from the standpoint of autoimmune diseases, particularly SLE, or immunosuppression.

Multiple dermatofibromas (DFs) are rare and have been thought to be associated with altered immunity. In this report, we describe a 27-year-old Japanese woman with systemic lupus erythematosus (SLE) and Sjgren’s syndrome in whom eight nodules had over Histopathological findings were consistent with DF. SLE rather than Sjögren’s syndrome seemed to have induced the multiple DFs in this patient. We also reviewed the reported cases with multiple DFs associated with SLE and / or Sjögren’s syndrome . Review of the previous reports indicates that SLE is the most frequent autoimmune disorder associated with multiple DFs, and that both SLE and immunosuppressive treatments play a part in induction of multiple DFs. Thus, if multiple DFs are present it is important that the status of the patient be evaluated from the standpoint of autoimmune diseases, particularly SLE, or immunosuppression.