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最近认识到肺循环除能进行气体交换外,还能够摄取、灭活或激活一些循环化合物,合成和释放其他物质,即所谓肺的代谢活动。肺的代谢活动有助于调节某些重要的生理机能,如肺血管和气道平滑肌的紧张性,肺微小血管的通透性,局部和整体肺血量以及体循环动脉血压。一、由细胞内酶摄取和降解的化合物 1.5-羟色胺,1925年Starling等人指出一种“血清缩血管物质”在通过心肺制备时被“解毒”,后来证明这种物质是5-羟色胺。5-羟色胺在通过猫的灌流肺时被灭活。以后许多哺乳动物的实验证明肺能够有效地清除5-羟色胺。肺处理5-羟色胺包括摄取降解过程。摄取是可饱和的、需能的、与
Recently, it has been recognized that in addition to being able to exchange gas with the pulmonary circulation, it is also capable of ingesting, inactivating or activating some circulating compounds to synthesize and release other substances, the so-called metabolic activities of the lungs. The metabolic activity of the lungs helps to regulate certain important physiological functions such as the tension of the pulmonary and airway smooth muscles, the permeability of the pulmonary microvasculature, local and global pulmonary blood flow, and systemic arterial blood pressure. A compound, 1.5-HT, which is uptake and degradation by intracellular enzymes. Starling et al. In 1925 indicated that a “vasoconstrictor substance” was “detoxified” when prepared through the heart and lung and subsequently was shown to be serotonin. Serotonin is inactivated as it passes through the cat’s perfusion lung. Many later mammalian experiments demonstrated that the lungs were able to effectively eliminate serotonin. Pulmonary treatment of serotonin includes uptake and degradation processes. Ingestion is saturable, needed, with