Chronic Toxicity of a Novel Recombinant Human Granulocyte Colony-stimulating Factor in Rats

• 作 者: Fei Xia Qing-yu Zhang Yong-pin
• 机 构: BiopharmaceuticalR&,DCenter,BiopharmagenCorporation
• 出 处: 中国医学科学杂志：英文版
• 发表日期: 2011年1期
• 关键词: 重组人粒细胞集落刺激因子 SD大鼠 慢性毒性 剂量效应关系 病理组织学检查 血细胞计数 中性粒细胞 皮下注射 chronic toxicity Sprague-
• 基金项目: ASupported by State Scientific Key Projects for New Drug Research and Development （2009ZX09102-250） and High-tech Research Project for Medicine and Pharmacology of Jiangsu Province （BG20070605）.

Objective To assess the severity and reversibility of the chronic toxicity of a novel recombinant human granulocyte colony-stimulating factor (rhG-CSFa) in rats and the dose-effect relationship.Methods A total of 100 Sprague-Dawley rats (equal numbers of