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目的研究氟哌利多与托烷司琼预防腹腔镜结直肠癌根治术后恶心呕吐(PONV)的临床效果。方法以120例腹腔镜结直肠癌根治术患者为研究对象,随机分成氟哌利多(Ⅰ组)、托烷司琼(Ⅱ组)和氟哌利多联合托烷司琼(Ⅲ组)。观察术后24h各组PONV的发生情况。结果Ⅲ组PONV发生率明显低于Ⅰ组、Ⅱ组,有统计学意义(P<0.05)。Ⅰ组与Ⅱ组比较无统计学意义(P>0.05)。结论托烷司琼联合氟哌利多可有效地减少腹腔镜结直肠癌根治术后PONV的发生。
Objective To study the clinical effects of droperidol and tropisetron on prevention of postoperative laparoscopic radical resection of colorectal cancer with nausea and vomiting (PONV). Methods 120 patients undergoing laparoscopic radical resection of colorectal cancer were randomly divided into droperidol (group Ⅰ), tropisetron (group Ⅱ) and droperidol plus tropisetron (group Ⅲ). The incidence of PONV in each group was observed 24h after operation. Results The incidence of PONV in group Ⅲ was significantly lower than that in group Ⅰ and group Ⅱ (P <0.05). There was no significant difference between group Ⅰ and group Ⅱ (P> 0.05). Conclusion Tropisetron plus droperidol can effectively reduce the incidence of PONV after laparoscopic radical resection of colorectal cancer.