Elevated Levels of Serum IgA against Saccharomyces cerevisiae Mannan in Patients with Rheumatoid Art

• 作 者: Hui Dai Zhanguo Li Yan Zhang Ping Lv Xiao-Ming Gao
• 机 构: Department of Immunology. Peking University Health Science Center, Peking University, Beijing, China
• 出 处: 中国免疫学杂志（英文版）
• 发表日期: 2009年5期
• 关键词: autoantibody α-1 3-mannan autoimmune diseases RA

This study was undertaken to investigate whether levels of anti-Saccharomyces cerevisiae mannan antibodies (ASCMA) in human sera, a marker for several autoimmune diseases, correlate with rheumatoid arthritis (RA). ASCMA-IgA, -IgG and -IgM levels were measured with enzyme linked immunosorbent assays (ELISA) in patients with RA (n=30) and 152 healthy adult controls. ASCMA-IgA prevalence was significantly higher in RA patients (40%) than in healthy subjects (5.3%). A strong correlation between levels of ASCMA-IgA and CRP (r=0.695; p < 0.01) and ESR (r=0.708; p<0.01) in RA patients was observed. No significant differences in ASCMA-IgG or IgM levels were noted between RA patients and healthy control subjects in the present study. This result differs from previous reports. It remains to be evaluated whether elevated ASCMA-Ieveis are common to all rheumatic disorders. Cellular & Molecular Immunology. 2009;6(5):361-366.