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口服避孕药对肝脏的损害,可由药物对肝脏的直接毒性引起,也可因加重肝脏原有疾患所致。肝内胆汁郁积口服避孕药引起肝内胆汁郁积发生率为1/4000～1/10000。与妊娠肝内胆汁郁积密切相关。绝大多数在第1个周期发病,表现为厌食、恶心、呕吐、疲乏、体重减轻和皮肤瘙痒,数天后发生黄疸。多无发热、皮疹或腹痛。血清结合胆红素和转氨酶升高,部分病例碱性磷酸酶升高。肝活检见小管内有胆栓,电镜见小管扩张、胆汁沉积和微绒毛异常。停药后1～3月,症状和组织
Oral contraceptives on the liver damage can be caused by the direct toxicity of drugs on the liver, but also due to aggravate the original liver disease. Intrahepatic cholestasis oral contraceptives cause intrahepatic cholestasis incidence of 1/4000 ~ 1/10000. Intrahepatic cholestasis and pregnancy are closely related. The vast majority of the first cycle of onset, manifested as anorexia, nausea, vomiting, fatigue, weight loss and itchy skin, jaundice occurred days later. No fever, rash or abdominal pain. Serum bilirubin and aminotransferase increased, in some cases increased alkaline phosphatase. Liver biopsy showed gallbladder within the small tube, electron microscope, tubule expansion, cholestasis and abnormal microvilli. After stopping 1 to 3 months, symptoms and tissues