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接触式变焦显微内窥镜是内窥镜技术的一项新进展。这种新型内窥镜既可作为常规硬管内窥镜全景检查,也可进行显微检查。最大放大倍数为150倍,分辨率达到细胞水平。该作者应用接触式变焦显微内窥镜结合活体染色技术对860例不同鼻咽病变(其中确诊为鼻咽癌者106例)进行检查。经观察比较,鼻咽癌病灶及癌旁粘膜镜下所见有以下特征:粘膜上皮着色不均,变性坏死的脱落细胞较多;微血管曲张、畸变、易出血;细胞形态不一,排列不规则,多为过渡型上皮及鳞状化生细胞,伴有不同程度的增生及角化;常有较多的淋巴细胞、裸核细胞及核大深染的异型细胞,偶见可疑癌细胞。活体粘膜染色接触式显微内窥镜扫描观察,不但有助于早期发现病灶,准确取材作病检,对研究鼻咽癌及癌前病变其活体原位粘膜上皮细胞和微血管的变化也具有一定的意义。
Contact zoom microscope endoscope is a new development of endoscopic technology. This new endoscope can be used as a routine panoramic endoscopic examination, but also for microscopic examination. The maximum magnification is 150 times, the resolution reaches the cell level. The authors used contact-type zoom microscopic endoscopy combined with biopsy techniques to examine 860 different nasopharyngeal lesions (of which 106 were diagnosed with nasopharyngeal carcinoma). After observation and comparison, there are the following characteristics in the lesions of nasopharyngeal carcinoma and adjacent mucosa: mucosal epithelial uneven coloring, more exfoliative cells of degeneration and necrosis; microvascular varicose, distortion and hemorrhage; irregularly arranged cells , Mostly transitional epithelial and squamous metaplastic cells, accompanied by varying degrees of proliferation and keratosis; often more lymphocytes, naked nucleated cells and large nucleated stained cells, and occasionally suspicious cancer cells. In vivo mucosal staining contact micro-endoscopic scanning observation, not only helps to early detection of lesions, accurate drawing for disease control, nasopharyngeal carcinoma and precancerous lesions of its in situ mucosal epithelial cells and microvascular changes also have a certain Meaning.