Implication of Expression of Osteopontin and Its Receptor Integrin αvβ3 in the Placenta in the Devel

• 作 者: 夏俊霞 乔福元 苏放明 刘海意
• 机 构: Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong Universit
• 出 处: Journal of Huazhong University of Science and Technology(Med
• 发表日期: 2009年06期
• 关键词: preeclampsia integrin pregnant Integrin placental placenta Osteopontin Receptor

To investigate the expression of osteopontin (OPN) and its receptor integrin αvβ3 in the placental tissue from pregnant women complicated with preeclampsia, the expression of OPN and αvβ3 in the placenta of the pregnant women with preeclampsia and healthy pregnant women was detected by immunohistochemistry, Western blotting and RT-PCR. Our results showed that OPN and αvβ3 protein were expressed in the placenta from normal pregnant woman and those with preeclampsia. OPN was located in the placental syncytiotrophoblasts and the cytoplasm of capillary endothelial cells and integrin αvβ3 was mainly expressed on the surface of trophoblast cells. Expression of OPN and integrin αvβ3 in the placental tissue from preeclampsia subjects was significantly lower than that from the control group (P<0.05). Compared with the control group, expression of OPN in the placental tissue from preeclampsia group was significantly lower (P<0.05) but there was no significant difference in the expression of αv and β3 between the preeclampsia group and the controls. It is concluded that OPN and its receptor integrin αvβ3 may be involved in the pathogenesis of preeclampsia.

To investigate the expression of osteopontin (OPN) and its receptor integrin αvβ3 in the placental tissue from pregnant women complicated with preeclampsia, the expression of OPN and αvβ3 in the placenta of the pregnant women with preeclampsia and healthy pregnant women was detected by immunohistochemistry, Western OPN was located in the placental syncytiotrophoblasts and the cytoplasm of capillary endothelial cells and integrin αvβ3 was mainly expressed on the surface of trophoblast cells. Expression of OPN and integrin αvβ3 in the placental tissue from preeclampsia subjects was significantly lower than that from the control group (P <0.05). Compared with the control group, expression of OPN in the placental tissue from preeclampsia group was significantly lower (P <0.05) but there was no significant difference in the expressi on of αv and β3 between the preeclampsia group and the controls. It is said that that OPN and its receptor integrin αvβ3 may be involved in the pathogenesis of preeclampsia.