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目的检测血管内皮生长因子(VEGF)和基质金属蛋白酶-9(MMP-9)在乳腺癌中的表达情况,研究两者与淋巴结转移的关系。方法采用免疫组化SP法检测92例乳腺浸润癌中VEGF、MMP-9的表达情况。结果 VEGF蛋白在对照组和乳腺癌组中的阳性表达率分别为6.7%(3/45)和90.2%(83/92),且VEGF在淋巴结转移组中的阳性表达率(53/55)明显高于无淋巴结转移组(P<0.05)。MMP-9蛋白在正常乳腺组织及乳腺癌中的阳性表达率分别为0(0/45)和92.4%(85/92),而且MMP-9在淋巴结转移组中的阳性表达率(54/55)明显高于无淋巴结转移组(P<0.05)。结论 VEGF、MMP-9蛋白在乳腺癌组织中高表达,且均与淋巴结转移有关(P<0.05),两者可能在乳腺癌的远处转移中起协同作用。
Objective To detect the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in breast cancer and to study their relationship with lymph node metastasis. Methods Immunohistochemical SP method was used to detect the expression of VEGF and MMP-9 in 92 cases of invasive breast cancer. Results The positive rates of VEGF protein in control group and breast cancer group were 6.7% (3/45) and 90.2% (83/92), respectively. The positive rate of VEGF expression in lymph node metastasis group (53/55) Higher than those without lymph node metastasis (P <0.05). The positive rates of MMP-9 protein in normal breast tissues and breast cancer tissues were 0 (0/45) and 92.4% (85/92) respectively, and the positive rates of MMP-9 in lymph node metastasis (54/55 ) Was significantly higher than that without lymph node metastasis (P <0.05). Conclusions The expressions of VEGF and MMP-9 are highly expressed in breast cancer tissues, and both are correlated with lymph node metastasis (P <0.05), both of which may play a synergistic role in the distant metastasis of breast cancer.