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目的探讨病理性妊娠患者血清ACA、β-HCG表达水平及其与病理性妊娠发病的相关性。方法 选择在我院门诊行产前检查的孕妇122例,其中病理性妊娠组82例和正常妊娠组40例。采用酶联免疫法(ELISA)检测两组血清ACA的含量以及电化学发光免疫法(ECLIA)检测β-HCG的含量。结果病理性妊娠组孕妇血清ACA和β-HCG水平均明显高于正常妊娠组(P<0.05);病理妊娠组组内比较,血清ACA和β-HCG水平差异无统计学意义(P>0.05)。病理性妊娠组和正常妊娠组孕妇血清ACA与β-HCG表达均呈正相关性(r=0.458、0.693,P<0.05或0.01)。结论妊娠期间监测高危孕妇血清ACA以及β-HCG水平能早期发现、早期诊断病理性妊娠。
Objective To investigate the expression of serum ACA and β-HCG in patients with pathological pregnancy and its correlation with the pathogenesis of pathological pregnancy. Methods 122 cases of prenatal examination in our hospital outpatient prenatal care, including 82 cases of pathological pregnancy group and 40 cases of normal pregnancy group. Serum ACA levels were measured by enzyme-linked immunosorbent assay (ELISA) and β-HCG levels by electrochemiluminescence immunoassay (ECLIA). Results Serum levels of ACA and β-HCG in pregnant women with pathological pregnancy were significantly higher than those in normal pregnant women (P <0.05). There was no significant difference in serum ACA and β-HCG between pregnant women and pregnant women (P> 0.05) . Serum ACA and β-HCG expression were positively correlated with pregnant women and normal pregnant women (r = 0.458, 0.693, P <0.05 or 0.01). Conclusion Serum levels of ACA and β-HCG in high-risk pregnancies during pregnancy can be detected early and early diagnosis of pathological pregnancy.