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P~(53)基因的突变或缺失是许多肿瘤发生的原因。甲状腺癌的发生发展与癌基因，抑癌基因的异常调控密切相关。近几年P‘’蛋白通过免疫组化方法在肿瘤中的定位文献报道已非常活跃，但有关P’‘在甲状腺肿瘤中表达报道不多。本实验应用免疫组化方法检测P’‘在甲状肿瘤中的异常表
The mutation or deletion of P53 gene is the cause of many tumors. The occurrence and development of thyroid cancer are closely related to the abnormal regulation of oncogenes and tumor suppressor genes. In recent years, the localization of P′’ proteins in tumors by immunohistochemistry has been reported to be very active, but there has been little report on the expression of P′′ in thyroid tumors. In this experiment, immunohistochemistry was used to detect abnormalities in thyroid tumors.