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前列腺素D2(PGD2)及其受体介导的信号转导途径在变态反应、气道炎症改变、气道高反应性3个方面起着重要作用,因此受到越来越多学者的关注。本文从以上3个方面综述了PGD2及其受体介导的信号转导途径在哮喘发生中的作用。
Prostaglandin D2 (PGD2) and its receptor-mediated signal transduction pathways play an important role in the allergic reaction, airway inflammation and airway hyperresponsiveness, and are therefore attracting more and more scholars’ attention. This article reviews the role of PGD2 and its receptor-mediated signal transduction pathway in the pathogenesis of asthma from the above three aspects.