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目的观察普米克令舒(吸入用布地奈德混悬液)氧气驱动雾化吸入和并口服易维适(乙酰半胱氨酸胶囊)在慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效。方法将90例AECOPD的住院患者随机分为治疗组和对照组,治疗组给予普米克令舒2 mg氧气驱动雾化吸入2次/d,并同时口服易维适0.2 g,3次/d。对照组常规给予雾化治疗,氯化钠溶液20 ml,α糜蛋白酶4 000 U,氨茶碱注射液0.25 g,2次/d。观察两组患者治疗14 d的呼吸困难评分,咳嗽、喘憋症状改善;肺内啰音减少;血气分析;肺功能(FEV1/FVC)变化情况。结果治疗14 d两组患者的上述指标治疗组有效率明显高于对照组。结论普米克令舒雾化吸入联合易维适治疗慢性阻塞性肺疾病急性加重期为有效治疗方法。
Objective To observe the clinical effect of pulmicort respules (inhalation of budesonide suspension) aerosol driven aerosol inhalation and oral administration of Yi Wei Qi (acetylcysteine capsules) in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) . Methods 90 hospitalized patients with AECOPD were randomly divided into treatment group and control group. Patients in the treatment group received inhalation of Pulmicort respules 2 times a day for 2 days, while those in the control group received oral administration of 0.2 grams of quetiapine for 3 times daily. Control group routinely given nebulization, sodium chloride solution 20 ml, 4 000 U of α-chymotrypsin, aminophylline injection 0.25 g, 2 times / d. The scores of dyspnea, cough and wheezing were observed on the 14th day in both groups. The pulmonary rales were reduced. The blood gas analysis and the changes of pulmonary function (FEV1 / FVC) were also observed. Results The effective rate of the above indicators in the two groups of patients on the 14th day of treatment was significantly higher than that of the control group. Conclusion Pulmicort respiration inhalation combined with easy-to-treat chronic obstructive pulmonary disease acute exacerbation as an effective treatment.