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白蛋白微球剂是以白蛋白作为赋形剂而制得的一种微球形药物载体,它是把药物镶嵌于蛋白质的网状孔隙中,经表面活性剂乳化而成的微粒。调整制备条件可使粒径控制在0.3～500μm之间,在研究初期,制备约为血管末稍直径2～3倍的微球,作为血液循环的诊断药使用。目前,临床上作为肺和肝的造影剂,曾给8375名患者进行肺造影,其中只有2人有副作用。1974年,Kramer指出,白蛋白微球可作为靶向性的药物载体,此后进行了大量研究,已用作盐酸阿霉素(Adriamycin,ADM),5-氟脲密啶(5-Fluorouracil,5-FU),
Albumin microsphere agent is albumin as an excipient and made of a microspherical drug carrier, which is the drug embedded in the network of protein pores, the surfactant emulsified particles. Adjust the preparation conditions can make the particle size control between 0.3 ~ 500μm, at the beginning of the study, the preparation of about 2 to 3 times the diameter of the end of the blood vessels microspheres, as a diagnostic reagent for blood circulation. Currently, clinically as a contrast agent for lung and liver, 8375 patients had pulmonary angiography, of which only 2 had side effects. In 1974, Kramer pointed out that albumin microspheres can be used as targeted drug carriers and a large number of studies have been conducted since then. They have been used as Adriamycin (ADM), 5-Fluorouracil -FU),