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抗核抗体(antinuclear antibody,ANA)是多种自身免疫性疾病(autoimmune disease,AID)特别是ANA相关风湿性疾病诊断的重要血清学标志物。以HEp-2细胞为基质的间接免疫荧光法是ANA检测的重要方法,被美国风湿病学会、欧洲自身免疫标准化促进会等专业学会推荐为ANA检测的参考方法。
Antinuclear antibodies (ANA) are important serological markers for the diagnosis of many autoimmune diseases (AIDs), especially ANA-related rheumatic diseases. Indirect immunofluorescence with HEp-2 cells as the substrate is an important method for the detection of ANA. ANA is recommended as a reference method for ANA testing by the American College of Rheumatology and European Association for the Advancement of Autoimmunity.