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胃癌是全世界发病率和死亡率排名第二位的恶性肿瘤,而我国是世界上胃癌发病率最高的国家之一.细胞周期蛋白的调控能对肿瘤的机制研究及基因治疗提供有效依据.细胞周期中的G1/S期是调控的关键点,其中Cyclin D1、P16及CDK4基因起着重要的作用,且与胃癌之间有着较大的关联性,但上述基因与胃癌之间的关系尚不明确.为了更好地认识Cyclin D1、P16及CDK4基因在胃癌中表达的情况,就近年来相关的研究进行综述.
Gastric cancer is the second highest incidence and mortality of malignant tumors in the world, and our country is one of the countries with the highest incidence of gastric cancer in the world.The regulation of the cell cycle proteins can provide an effective basis for the mechanism of tumor research and gene therapy. The G1 / S phase of the cycle is the key point of regulation. Cyclin D1, P16 and CDK4 genes play an important role, and have a greater correlation with gastric cancer, but the relationship between these genes and gastric cancer is not yet In order to better understand the expression of Cyclin D1, P16 and CDK4 genes in gastric cancer, the related researches in recent years are reviewed.