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除了青蒿素类衍生物,疟原虫可能对每一种抗疟药都产生了耐药性。同类药物之间的交叉耐药使这个问题更加严重。在许多热带地区引进乙胺嘧啶后,间日疟原虫(P.v.),恶性疟原虫(P.f.)对抗叶酸类化合物的耐药性发展迅速;在甲氟喹常规应用之前已有疟原虫对其耐药的报道,现已严重阻碍该药在东南亚一些地区的应用;对卤泛曲林的耐药性也随之发生;当阿托喹酮单独使用
In addition to artemisinin derivatives, Plasmodium may be resistant to every antimalarial drug. This problem is exacerbated by the cross-resistance between similar drugs. After introduction of pyrimethamine in many tropical areas, resistance of Plasmodium vivax (Pv) and Plasmodium falciparum (Pf) to folic acid compounds has developed rapidly; Plasmodium has been resistant to it before routine use of mefloquine Reported that it has seriously hindered the application of the drug in some areas in Southeast Asia; the resistance to halibutramine also occurs; when atorvastatin alone