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本试验应用从加拿大引种自发性糖尿病大鼠(简称BB Wistar大鼠)进行一年半的饲养繁殖试验。通过对该动物的生长发育、代谢观察及脏器重量等项指标的检测以及对影响其子代发病率的因素进行了讨论。结果证明:自发性糖尿病大鼠后代发病率较高(10％～39％),不同家系内和亲代不同交配方式影响子代发病率。此外,发病鼠的生长发育、机体代谢与人类青年型糖尿病十分相似。BB Wistar大鼠可作为一种自发性动物模型用于人类青年型糖尿病及其并发症的研究。
In this study, a one-and-a-half-year feeding and breeding experiment was conducted in Canada using spontaneously diabetic rats (BB Wistar rats). Through the animal’s growth and development, metabolic observation and organ weight and other indicators of the detection and the factors affecting the incidence of their offspring were discussed. The results showed that the incidence of offspring in spontaneously diabetic rats was higher (10% to 39%), and mating patterns in different families and parents affected the incidence of offspring. In addition, the growth and development of diseased mice, body metabolism and human youth type diabetes are very similar. BB Wistar rats can be used as a spontaneous animal model for the study of human youth type diabetes and its complications.