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大肠癌是消化道常见恶性肿瘤,其发病率在我国位居第五位,在消化道恶性肿瘤中居第三位,近年来发病率呈上升趋势,平均5年生存率不足30%,主要死亡原因是肿瘤浸润和转移,而肝转移是其最常见的转移部位。基底膜和细胞外基质是瘤细胞浸润和转移的主要屏障。乙酰肝素酶(Hpa)是目前在哺
Colorectal cancer is a common malignant tumor of the digestive tract. Its incidence is the fifth in China and the third in malignant tumors of the digestive tract. The incidence of colorectal cancer is on the rise in recent years, with an average 5-year survival rate of less than 30%. The major causes of death Is tumor infiltration and metastasis, and liver metastasis is its most common site of metastasis. The basement membrane and the extracellular matrix are the major barriers to tumor cell invasion and metastasis. Heparanase (Hpa) is currently in the feed