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随机临床试验已证实静脉溶栓、β肾上腺能阻滞剂、抗凝剂和阿斯匹林可减少急性心肌梗塞近期病死率和预防其并发症;理论上,随着上述治疗措施的运用,急性心肌梗塞的死亡应显著减少,但所有这些临床试验都有选择偏倚,而且这些治疗手段在日常治疗中的使用情况又不一致。本文通过大系列人群的长期流行病学监测结果来评价这些新的治疗手段对急性心肌梗塞住院病死率的影响。 本文研究采用加拿大安大略州各大医院1981至1991年奇数年出院主要诊断为急性心肌梗塞的所有病例的计算机贮存资料。但属
Randomized clinical trials have confirmed that intravenous thrombolysis, beta adrenergic blockers, anticoagulants and aspirin can reduce the recent mortality and prevent complications of acute myocardial infarction; in theory, with the above treatment measures, acute Death from myocardial infarction should be significantly reduced, but all of these clinical trials have a bias of choice, and the use of these treatments in routine care is not consistent. In this article, the long-term epidemiological surveillance of large populations will be used to assess the impact of these new treatments on in-hospital mortality in patients with acute myocardial infarction. In this study, computerized data were collected from all cases of major MI diagnosed as acute myocardial infarction in the odd years from 1981 to 1991 at major hospitals in Ontario, Canada. However,