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目的:分析肝细胞癌(HCC)患者多层螺旋CT(MSCT)扫描征象及与其组织血管内皮生长因子(VEGF)表达水平的相关性。方法:回顾性分析2015年4月至2018年12月本院收治的51例HCC患者，比较HCC组织与癌旁组织VEGF阳性率、微血管密度(MVD)水平，HCC组织VEGF阳性与阴性患者MVD水平，MSCT不同扫描征象患者血管生成指标水平，并分析MSCT扫描征象与VEGF、MVD的相关性。结果:HCC组织VEGF阳性率(80.39%)高于癌旁组织(23.53%)，MVD大于癌旁组织(n P0.05)；假包膜无/欠完整患者VEGF阳性率、MVD高于完整患者，高危侵袭患者VEGF阳性率、MVD大于低危患者，动脉供血型患者VEGF阳性率、MVD大于双重供血、少供血型患者(n P0.05). The VEGF positive rate and MVD in patients with pseudocapsule without / incomplete were higher than those in patients with intact capsule; the VEGF positive rate and MVD in patients with high risk invasion were higher than those in patients with low risk; the VEGF positive rate and MVD in arterial blood supply were higher than those in patients with dual supply and insufficient blood supply (n P<0.05); MSCT scan showed that false capsule without / incomplete, high risk of invasion, arterial blood supply and double supply were positively correlated with VEGF and MVD, while less blood supply was negatively correlated with VEGF and MVD (n P<0.05).n Conclusions:MSCT scan can accurately evaluate the size of HCC lesions, the presence of false capsule, invasion and metastasis, enhancement type, etc. No/incomplete pseudocapsule, high-risk invasion, arterial blood supply and dual supply are positively correlated with VEGF and MVD, while less blood supply is negatively correlated with VEGF and MVD. This can pro-vide a new rapid, simple and non-invasive examination method for the evaluation of tumor neovascularization and diagnosis and prognosis for HCC.