论文部分内容阅读
据《N Engl J Med》2001年345卷第10期报道 手术切除胃腺癌治愈的病例<40％。美国纽约市圣·文森特综合癌症中心John s.Macdonald博士等,调查研究了手术切除加术后放化疗(辅助治疗)对可切除胃或胃食管界腺癌病人生存期的影响。共计556例病人随机指定接受手术加术后放化疗或单独手术。辅助治疗包括氟尿嘧啶425mg/m~2体表面积/d+甲酰四氢叶酸20mg/m~2体表面积/d,共5天;随后进行放疗180cGy/d,每周5天共5周,总量为4500cGy。在放疗的最初4天和最后3天调
According to “N Engl J Med”, Vol. 345, No. 10, 2001, the number of cases of surgical resection of gastric adenocarcinoma was <40%. Dr. John S. Macdonald, Ph.D., St. Vincent Comprehensive Cancer Center, New York City, USA, investigated the effect of surgical resection plus postoperative radiotherapy and chemotherapy (adjuvant therapy) on the survival of patients with resectable gastric or gastroesophageal adenocarcinoma. A total of 556 patients were randomly assigned to surgery plus postoperative radiochemotherapy or surgery alone. Adjuvant therapy includes fluorouracil 425mg/m~2 body surface area/d+formyltetrahydrofolate 20mg/m~2 body surface area/d for 5 days; followed by radiotherapy 180cGy/d, 5 days per week for a total of 5 weeks. 4500cGy. In the first 4 days and the last 3 days of radiotherapy