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目的:探讨重度子痫前期患者脐动脉血流改变与胎盘病理学改变的相关性,从而预测妊娠的结局。方法:观察记录20例正常妊娠孕妇(对照组)、40例重度子痫前期患者(重度子痫前期组)的脐动脉血流参数S/D、阻力指数RI及采用免疫组织化学方法检测60例胎盘组织中凋亡促进因子Caspase-3的表达定位,从而分析脐动脉血流参数与病理改变的相关性。结果:重度子痫前期组Caspase-3在胎盘组织中的表达与对照组相比差异有统计学意义(P<0.05),随着妊娠期高血压疾病严重程度的增加,S/D、RI均呈增高趋势,S/D、RI与胎盘病理变化均有显著作用(P<0.01)。结论:随着S/D值、阻力指数RI的升高,重度子痫前期患者胎盘组织中的凋亡促进因子Caspase-3,可通过脐动脉血流的改变来判断胎盘的病理改变。
Objective: To investigate the correlation between changes of umbilical artery blood flow and pathological changes of placenta in patients with severe preeclampsia to predict the outcome of pregnancy. Methods: Umbilical artery blood flow parameters S / D, resistance index RI and immunohistochemistry were detected in 20 pregnant women (control group), 40 severe preeclampsia group (severe preeclampsia group) and 60 cases The expression and location of apoptosis promoting factor Caspase-3 in placenta tissue were analyzed to analyze the correlation between umbilical artery blood flow parameters and pathological changes. Results: The expression of Caspase-3 in the placenta of severe preeclampsia was significantly lower than that in the control group (P <0.05). With the increase of the severity of hypertensive disorders in pregnancy, both S / D and RI Showed an increasing trend, S / D, RI and placental pathological changes have a significant role (P <0.01). Conclusion: With the increase of S / D value and RI, the apoptosis promoting factor Caspase-3 in placental tissue of severe preeclampsia can be used to judge the pathological changes of placenta through the change of umbilical artery blood flow.