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目的评价镇平县农村地区艾滋病患者接受国家免费艾滋病抗病毒治疗前后服药依从性、毒副反应、免疫重建效果和身体状况恢复情况等。方法采用简单随即抽样的方法,抽取2006年7月1日后镇平县新加入治疗的175例病人,分析治疗前后相关临床和实验室检查情况的变化情况,从毒副反应、服药依从性、体重和CD4T淋巴细胞变化情况等方面评价抗病毒治疗效果。结果(1)治疗前,病人CD4T淋巴细胞计数为174.0个±146.4个/μL;治疗后CD4T淋巴细胞计数明显升高,治疗12个月、18个月和24个月后CD4T淋巴细胞计数平均分别上升49.7、65.1和127.8个/μL,差异有统计学意义(P<0.05);(2)CD4T淋巴细胞计数水平分类情况来看,CD4T<100个/μL的比例从基线的33.14%降低为治疗24个月时6.98%,(100~199)个/μL的比例从基线的36.57%降低为治疗24个月时18.60%;(200~349)个/μL的比例从基线的20.00%升高为治疗24个月时53.49%,CD4T>350个/μL的比例从基线的10.29%升高为治疗24个月时20.93%。(3)病人体重平均水平从治疗前(58.3 kg±7.7 kg)到治疗18个月(60.6 kg±7.3 kg)和24个月(60.8 kg±8.1 kg)时,体重平均增加2.3 kg和2.5 kg,差别具有统计学意义。结论抗病毒治疗对H IV/AIDS具有较好的免疫重建效果,可以使病人恶病质状况得到改善。
Objective To evaluate the compliance of medication, side effects, immune reconstruction and recovery of physical condition of AIDS patients in rural areas of Zhenping County before and after receiving the national free AIDS antiviral therapy. Methods A total of 175 new patients were recruited in Zhenping County from July 1, 2006 after sampling. The changes of clinical and laboratory tests before and after treatment were analyzed. The adverse reactions, medication compliance, body weight And CD4T lymphocyte changes in areas such as evaluation of antiviral treatment. Results (1) Before treatment, the CD4 T lymphocyte count of patients was 174.0 ± 146.4 / μL; the counts of CD4 T lymphocytes increased significantly after treatment, and the average counts of CD4 T lymphocytes after 12, 18 and 24 months treatment were respectively (P <0.05). (2) The classification of CD4 T lymphocyte count showed that the proportion of CD4 T <100 cells / μL decreased from 33.14% of baseline to treatment At 24 months, the proportion of (99%) / μL decreased from 36.57% at baseline to 18.60% at 24 months of treatment. The proportion of (200 ~ 349) / μL increased from 20.00% at baseline to The proportion of CD4 T> 350 cells / μL increased from 10.29% at baseline to 20.49% at 24 months after treatment at 53.49% at 24 months. (3) The average body weight of the patients increased by 2.3 kg and 2.5 kg on average from the pre-treatment (58.3 kg ± 7.7 kg) to the 18-month treatment (60.6 kg ± 7.3 kg) and 24 months (60.8 kg ± 8.1 kg) , The difference was statistically significant. Conclusion Antiviral therapy has a good immune reconstitution effect on H IV / AIDS, which can improve the patient’s cachexia status.