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各种显带技术的应用,显示人类染色体有大范围的可变的染色体异态性区。一些研究应用喹吖因荧光异态性估计母系和父系的减数分裂差错的数量。联合应用几种染色体技术,能鉴别许多患者的两个21号染色体,并能鉴别Down综合征患者三个21号染色体的来源。本文研究了丹麦Funen和Zealand两地区110个Down综合征患者的家庭的不分离,其中76%的病例查明了不分离事件的发生。比较Down综合患儿和双亲的21号染
The application of various visualization techniques shows that the human chromosome has a wide range of variable chromosomal abnormalities. Some studies used quinacrine fluorescence inhomogeneity to estimate the number of meiosis and paternal meiosis errors. The combination of several chromosomal techniques can identify two chromosomes 21 in many patients and identify the origin of three chromosomes 21 in Down syndrome. This study examined the non-segregation of families of 110 Down syndrome patients in Funen and Zealand, Denmark, where 76% of cases identified non-segregated events. Compare Down with children and parents of the 21st dyed