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氧氟沙星(氟嗪酸、泰利必妥、OFLX)为新一代氟喹诺酮类抗菌药,因其抗菌活性高于诺氟沙星、培氟沙星、依诺沙星,且抗菌谱广,口服吸收良好,不良反应轻微等特点,被临床广泛应用。但近年来发现一些严重不良反应,现作综合评价,为临床应用提供参考。1 不良反应1.1 过敏性休克 陈秀丽报道一女性患者,1966年,因慢性支气管炎、阻塞性肺气肿入院。经询问既往史,该患者既往无高血压、心脏病及过敏史。经查体:BP 100/70mmHg,意识
Ofloxacin (ofloxacin, telcillin, OFLX) is a new generation of fluoroquinolone antibacterial drugs, because of its antibacterial activity than norfloxacin, pefloxacin, enoxacin, and broad antibacterial spectrum, Oral absorption of good, minor adverse reactions, etc., are widely used in clinical. In recent years, however, we have found some serious adverse reactions and are now making a comprehensive evaluation for clinical application. 1 Adverse reactions 1.1 anaphylactic shock Chen Xiuli reported a female patient, 1966, due to chronic bronchitis, obstructive emphysema admitted. After asking the past history, the patient had no previous history of hypertension, heart disease and allergies. The physical examination: BP 100 / 70mmHg, awareness