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自1975年Fox发现结核病在接受利福平(RFP)和异烟肼(INH)强化治疗时出现类赫氏反应以来,国内外已陆续有报告。本文综合国内文献,就这个问题作一介绍。(一)概念所谓暂时恶化是指结核病,主要是肺结核在强化治疗早期出现伴或不伴排菌的X线上一过性病灶阴影扩大、病灶增多,出现空洞、淋巴结肿大和渗出性胸膜炎等,用原化疗方案继续治疗,病情稳定好转的现象。不包括化疗方案不合理治疗无效的真正恶化和继发肺部感染等,Fox把这种现象称为类赫氏反应,尔后五味称之为暂时恶化,此外还有人称为暂时性异常和治疗矛盾反应。
Since 1975, Fox discovered that tuberculosis has received Hirschstein-like reactions during intensive treatment with rifampicin (RFP) and isoniazid (INH), and reports have been reported at home and abroad. This article synthesizes domestic literature and introduces this issue. (A) the concept of the so-called temporary deterioration refers to the tuberculosis, tuberculosis mainly in the early stage of intensive treatment with or without bacterioplasty, a transient increase in shadow X-ray lesions, increased lesions, there is empty, swollen lymph nodes and exudative pleurisy , Continue treatment with the original chemotherapy regimen, stable condition improved phenomenon. Excluding the true worsening of chemotherapy ineffective treatment ineffective and secondary lung infections, Fox called this phenomenon Class Hertz reaction, then known as temporary deterioration of five flavors, in addition there are also known as temporary abnormalities and treatment of contradictions reaction.