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摘 要：目的 探讨99m Tc－TRODAT－1SPECT多巴胺转运体（dopamine transporter，DAT）显像评价帕金森病（PD）严重程度的意义。方法 对 18例健康自愿者、23例帕金森病患者行99m TC－TRODAT－1SPECT DAT断层显像，利用感兴趣区技术测定纹状体与小脑部位DAT比值。对PD患者进行UPDR评分和Hoehn－Yahr分级。结果 PD患者99m Tc－TRODAT－1SPECT DAT断层显像，纹状体DAT特异性摄取与 UPDR评分总分、日常活动评分、运动检查评分呈显著性负相关，与精神活动、行为、心境评分和PD患者年龄无相关性。结论99m Tc－TRODAT－1SPECT DAT断层显像有助于评估PD严重程度。
Abstract: Objective To investigate the significance of 99m Tc-TRODAT-1 SPECT dopamine transporter (DAT) imaging in evaluating the severity of Parkinson’s disease (PD). Methods Totally 99m Tc-TRODAT-1 SPECT DAT imaging was performed on 18 healthy volunteers and 23 patients with Parkinson’s disease. The DAT ratio of striatum and cerebellum was determined using the technique of region of interest. PD patients were UPDR and Hoehn-Yahr grading. Results The 99m Tc-TRODAT-1 SPECT DAT imaging in PD patients showed a significant negative correlation with UPDR score, daily activity score and exercise check score. There was significant negative correlation between DAT-specific uptake of striatum and mental activity, behavior, mood score and PD Patient age no correlation. Conclusion 99m Tc-TRODAT-1 SPECT DAT tomography can help assess the severity of PD.