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目的了解绵阳市健康人群麻疹抗体水平,掌握人群免疫状况,为制定有效的预防和控制措施提供科学依据。方法采用酶联免疫吸附试验(ELISA)对绵阳市不同年龄的健康人进行麻疹IgG抗体水平血清学检测,并对结果进行统计分析。结果共检测582份血清样本,人群几何平均滴度(GMT)为1∶817,抗体阳性522人,阳性率89.7%,抗体保护率76.6%;不同年龄组、不同地区的抗体水平存在显著差异,<8月龄的儿童和北川县人群的抗体阳性率、保护率及GMT均处于最低水平,不同性别间抗体水平无差异。结论绵阳市健康人群麻疹抗体处于中等偏上水平。加强流动儿童管理、提高接种质量、采取必要措施加强5岁以下儿童的疫苗接种工作和人群麻疹监测工作,是实现该市控制和消除麻疹目标的必要措施。
Objective To understand the level of measles antibody in healthy population in Mianyang and to understand the immune status of the population so as to provide a scientific basis for making effective prevention and control measures. Methods Serum IgG levels of measles IgG were detected by enzyme linked immunosorbent assay (ELISA) in healthy people of different ages in Mianyang City, and the results were statistically analyzed. Results A total of 582 serum samples were detected. The geometric mean titers (GMTs) were 1: 817, 522 were positive, the positive rate was 89.7% and the antibody protection rate was 76.6%. There were significant differences in antibody levels among different age groups and regions, The antibody positive rate, protection rate and GMT of children <8 months old and Beichuan county were at the lowest level, and there was no difference in antibody level among different sexes. Conclusion The measles antibody of healthy people in Mianyang City is in the upper middle level. Strengthening the management of migrant children, improving the quality of vaccination and taking the necessary measures to strengthen the vaccination of children under 5 and the monitoring of measles in the population are necessary measures to achieve the goal of controlling and eliminating measles in the city.