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miRNA是一类长约21～25 nt,进化上高度保守的单链非编码RNA。随着对miRNA研究逐渐深入,发现miRNA和转录因子(transcription factor,TF)可以同时调控同一基因,即转录因子又可通过影响miRNA间接的调控该基因表达,这种由miRNA、转录因子与靶基因三者组成的调控环路称为前馈环路(feed-forward loop,FFL)。miRNA-转录因子-靶基因形成的前馈环路在动脉粥样硬化与肿瘤发生发展过程中发挥了重要的调控作用,对这些疾病的机制和防治研究具有重要意义。
MiRNAs are a class of 21-25 nt, evolutionarily highly conserved, single-stranded, non-coding RNAs. With the progress of miRNA research, we found that miRNA and transcription factor (TF) can regulate the same gene at the same time. That is, transcription factor can indirectly regulate the expression of miRNA through miRNA, miRNA, transcription factor and target gene The control loop composed of the three is called feed-forward loop (FFL). The feedforward loop of miRNA-transcription factor-target gene plays an important regulatory role in the development of atherosclerosis and tumorigenesis, which is of great significance for the study of the mechanism and prevention and treatment of these diseases.