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用９９ｍＴｃ标记抗人活化血小板ＧＭＰ－１４０ＭＣＡｂＳＺ－５１，对实验性狗股动脉和股静脉血栓模型进行了免疫显像研究．结果表明：血栓显示清晰，其最佳显像时间为注射９９ｍＴｃ－ＳＺ－５１后４～６小时；９９ｍＴｃ－ＳＺ－５１引血液半清除时间Ｔ１／２α＝１６．２５±１３．３９分钟、Ｔ１／２β＝７．２８±１．１５小时；注射９９ｍＴｃ－ＳＺ－５１后８小时处死狗，离体血栓／血液和血栓／周围肌肉单位质量放射性比值：动脉血栓为５７．０９±１２．２４和１７７．４６±１１９．９３，静脉血栓为６．４３±４．７０和９４．４６±５７．５９；９９ｍＴｃ标记非特异ＩｇＧ，未见血栓显示．提示９９ｍＴｃ－ＳＺ－５１具有活体内导向定位血栓的能力，用于血栓性疾病的放免显像诊断有一定的可行性。
Immunohistochemical studies of experimental dog femoral and femoral vein thrombosis models were performed using 99mTc labeled anti-human activated platelet GMP-140MCAbSZ-51. The results showed that the thrombosis showed clear, the best imaging time was 4 ~ 6 hours after injection of 99mTc-SZ-51, the half-clearing time of 99mTc-SZ-51 blood was T1 / 2α = 16.25 ± 13.39 minutes, T1 /2β = 7.28 ± 1.15 hours; dogs were sacrificed 8 hours after injection of 99mTc-SZ-51, and the ratio of isolated thrombus / blood and thrombus / peripheral muscle mass radioactivity: arterial thrombus was 57.09 ± 12.24 and 177.46 ± 119.93, venous thrombosis was 6.43 ± 4.70 and 94.46 ± 57.59; 99mTc labeled non-specific IgG, no thrombus showed. It is suggested that 99mTc-SZ-51 has the ability of targeting thrombosis in vivo and it is feasible to diagnose thromboembolic disease by radioimmunoassay.