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BACKGROUND: Presently, clinic memory scale is used to evaluate leing memory ability in most studies,and the influence of difference in measurement condition of individuals exists.OBJECTIVE: To study the correlation between regional cerebral blood flow (rCBF) perfusion and leing memory function in special brain regions of patients with cerebral infarction at convalescent period,and to try to find out a method which can quantitatively evaluate leing ability.DESIGN: Case observation, and correlation analysis.SETTINGS: Shandong Institute for Behavioral Medicine; the Affiliated Hospital of Jining Medical College.PARTICIPANTS: Totally 70 patients with cerebral infarction admitted to Departtment of Neurology, Jining Medical College between January 2004 and December 2005 were involved. The involved patients, 58 male and 12 female, were averaged (52±3) years, and they were all right handed. They all met the diagnosis criteria instituted by the Fourth National Conference on Cerebrovascular Disease, and were confirmed as cerebral infarction by skull CT or MRI. Informed consents of detected items were obtained from all the patients and relatives.METHODS: When the patients were at convalescent period, their leing and memory ability were measured with clinic memory scale (set A). The 18 patients whose total mark over 100 were regarded as good leing memory function group; The 23 cases whose total mark less than 70 were regarded as poor leing memory function group. RCBF of hippocampus, nucleus amygdalae, temporal cortex and prefrontal lobe of patients between two groups were measured and compared by single photon emission computed tomography (SPECT). The total scores of the 18 good leing memory patients and 23 poor leing memory patients were taken as dependent variable Y, and their rCBFs of hippocampus, nucleus amygdale,temporal cortex and prefrontal lobe respectively as independent variable X for linear correlation analysis.MAIN OUTCOME MEASURES: Correlation of rCBF in different brain regions and leing memory ability in patients with cerebral infarction.RESULTS: ① The rCBF of hippocampus, nucleus amygdale, temportal cortex and prefrontal cortex of good leing memory function group were significantly higher than those of poor leing memory function group (P ＜ 0.05). ②In the good leing memory function group, rCBF of hippocampus, nucleus amygdale,temportal cortex and prefrontal cortex were significantly positively correlated with memory scale scores ( r =0.961, 0.926, 0.954, 0.907, P ＜ 0.05 ) , and also in the poor leing memory function group ( r = 0.979,0.976, 0.991, 0.953, P ＜ 0.05) .CONCLUSION: The rCBF of hippocampus, nucleus amygdale, temportal cortex and prefrontal cortex of patients with cerebral infarction are significantly positively correlated with memory scale scores. Predicting leing memory ability of patients by quantitative determination of rCBF provides a quantitative and objective method for evaluating leing memory ability.