论文部分内容阅读
目的比较经动脉灌注化疗栓塞(Transcatheter Arterial Chemoembolization,TACE)联合射频消融(Radiofrequency Ablation,RFA)治疗无法手术切除的原发性肝癌(Unresectable Hepatocellular Carcinoma,UHCC)与单独TACE治疗的临床远期疗效。方法通过计算机和手工检索全面收集国内关于TACE+RFA与单独TACE治疗无法手术切除肝癌的临床对照研究文献,并按Cochrane协作网推荐的方法进行Meta分析。采用RevMan 4.2软件,应用固定效应模型分析,对符合纳入标准的12个实验进行Meta分析。结果与单纯TACE相比,TACE+RFA的术后1年、2年及3年生存率高,差异有显著性(=1.36、1.78及2.61,<0.01)。结论TACE联合RFA治疗无法手术切除的肝癌的远期疗效较单独TACE治疗好,能有效提高患者生存率。
Objective To compare the long-term clinical efficacy of transcatheter arterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) in the treatment of unresectable Hepatocellular Carcinoma (UHCC) and TACE alone. Methods The computerized and manual retrieval methods were used to comprehensively collect the clinical control studies of unresectable hepatocellular carcinoma in China and TACE + RFA and TACE alone. Meta-analysis was performed according to the method recommended by the Cochrane Collaboration. Using RevMan 4.2 software, a meta-analysis of 12 experiments meeting the inclusion criteria was performed using the fixed-effects model analysis. Results Compared with pure TACE, the survival rates of TACE + RFA at 1 year, 2 years and 3 years after operation were significantly higher (= 1.36, 1.78 and 2.61, <0.01). Conclusion The long-term efficacy of TACE combined with RFA in the treatment of unresectable hepatocellular carcinoma is better than that of TACE alone, which can effectively improve the survival rate of patients.