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患者女,72岁,左小腿“糖尿病足”截肢术后丘疹、结节、溃疡伴痒半年,多次按湿疹、痒疹治疗无效。皮损伴明显瘙痒。半月前,外用药物后病情加重,皮损蔓延至对侧。结节组织病理提示:表皮局部呈杯状下陷,其内为坏死物质,下方为坏死变性的胶原,有真皮胶原纤维穿通现象,真皮浅层血管周围炎。Verhoeff-Van Gieson染色提示胶原纤维有穿通现象。诊断:反应性穿通性胶原病。
Female patient, 72 years old, left leg, “diabetic foot” amputation pimples, nodules, ulcers and itch for six months, many times by eczema, prurigo treatment ineffective. Lesions with obvious itching. Half a month ago, after exacerbations of exacerbations, skin lesions spread to the contralateral. Nodular histopathology tips: local epidermal cup was sinking, which is necrotic material, the bottom of the necrotic degeneration of collagen, there are dermal collagen fibers through the phenomenon of dermal perivascular inflammation. Verhoeff-Van Gieson staining suggests there is punch through of collagen fibers. Diagnosis: Reactive Percutaneous Collagen Disease.