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目的:探讨CDK4蛋白在膀胱移行细胞癌(BTCC)中的表达及其临床意义。方法:采用免疫组化方法,测定10例正常膀胱黏膜及40例BTCC标本中的CDK4蛋白的表达。结果:CDK4蛋白在正常膀胱黏膜和BTCC中的阳性表达率分别为0.00%、52.50%(P<0.05)。CDK4蛋白在G1、G2、G3中的阳性表达率依次为36.84%、61.54%、75.00%,差异无显著性(P>0.05);在Tis～T1中CDK4阳性表达率为40.00%,明显低于T2～T4中的73.33%(P<0.05)。结论:CDK4的过度表达可能在BTCC的进展中发挥了重要作用,CDK4可成为一种新的预后判断的参考指标。
Objective: To investigate the expression of CDK4 protein in bladder transitional cell carcinoma (BTCC) and its clinical significance. Methods: Immunohistochemical method was used to determine the expression of CDK4 protein in 10 normal bladder mucosa and 40 BTCC specimens. Results: The positive rates of CDK4 protein in normal bladder mucosa and BTCC were 0.00% and 52.50%, respectively (P <0.05). The positive rates of CDK4 protein in G1, G2 and G3 were 36.84%, 61.54% and 75.00%, respectively, with no significant difference (P> 0.05). The positive rate of CDK4 in Tis ~ T1 was 40.00% 73.33% of T2 ~ T4 (P <0.05). Conclusion: Overexpression of CDK4 may play an important role in the progression of BTCC. CDK4 may be a new reference for prognostic judgment.