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目的：研究脑不对称性对细胞因子和ＨＰＡ轴的影响。方法：用伸爪取食法将小鼠区分为左利、右利、双利动物，ＬＰＳ分别刺激２、４ｈ后取血浆用ＥＬＩＳＡ法检测ＩＬ－１β、ＩＬ－６、放免法测定血浆皮质酮含量。结果：左利组血浆ＩＬ－１β高于右利组，左利、右利组ＩＬ－１β均低于双利组。左利、右利组血浆皮质酮水平低于双利组。ＬＰＳ刺激后左利组ＩＬ－１β高于右利组，双利组亦高于右利组；左利、右利组血浆ＩＬ－６水平则均低于双利组。结论：脑不对称性对神经免疫内分泌网络有影响，左利者免疫紊乱发生率高可能与此有关。
AIM: To investigate the effects of brain asymmetry on cytokines and HPA axis. Methods: The rats were divided into ZOL, Right and Double LIFE rats by LEGA feeding method. The plasma was collected by LPS for 2 and 4 hours, respectively. IL-1β and IL-6 were measured by ELISA. Plasma corticosterone content. Results: The plasma IL-1β in Zuoli group was higher than that in dextromethorphan group. IL-1β in Zuoli and Renli group was lower than that in Shuangli group. Zuoli, right interest group, plasma corticosterone levels lower than Shuangli group. The level of IL-1β in Zuoli group was higher than that of right-winist group after LPS stimulation, and also higher than that of right-winist group in Shuangli group. The levels of IL-6 in Zuoli and Right-handed group were lower than those in Shuangli group. CONCLUSIONS: Brain asymmetry has an impact on the neuroendocrine endocrine network, and the high incidence of left-handed immune disorders may be related to this.