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经常受感染的病人与健康人相比,血中IgG亚类特别是IgG2/IgG4的浓度降低。临床上针对性地测定各种细菌抗原的抗体可以了解病人的免疫能力,还可区别IgG亚类浓度正常但特异性抗体缺乏者和普通IgG亚类缺乏者。抗人IgG亚类特异性单克隆抗体的获得促进了抗体鉴定的发展。在已发表的各种测定方法中,多数只测定单种细菌,甚至是单种抗原的抗体,仅有少数对几种不同抗原的应答的研究。本文报告一种测定在IgG亚类中特异性抗体的方法,选择3种细菌性抗原:
Often infected patients compared with healthy people, the blood IgG subclasses, especially IgG2 / IgG4 concentration decreased. Clinically targeted antibodies to various bacterial antigens can understand the patient’s immune capacity, but also to distinguish between the normal concentration of IgG subclasses, but the lack of specific antibodies and the general lack of IgG subclasses. The availability of anti-human IgG subclass-specific monoclonal antibodies has led to the development of antibody identification. Among the various published assays, the majority only test for antibodies against a single species of bacteria, even a single antigen, and only a few studies have responded to several different antigens. This article reports a method of determining specific antibodies in the IgG subclass by selecting three bacterial antigens: