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根据病人性别、年龄和FAB形态学分类标准以及染色体发现、对治疗反应和生存期,作者在6年半的时间里对90例MDS和194例AML进行了研究随访。90例MDS包括男性63例,女性27例,年龄17-98岁。中位年龄64岁,11例病人在50岁以下。194例AML男性122例,女性72例,年龄16-94岁,中位年龄50岁。 MDS有66例(73%)染色体异常,24例染色体正常。共分8个染色体类型:单纯5q缺失;-7或7q缺失;+8;20q缺失;一个混合缺陷;两个混合缺陷;复合缺陷和正常染色体。染色体正常者和5q缺失(主要为RA)预后较好,两组31例有29例中位随访期为18个月,12例病人随访超过3年。8号三倍体,7q缺失/-7或有复合缺陷的37例只有2例存活,
According to the patient’s sex, age, and FAB morphological classification criteria and chromosomal findings, the authors followed 90 patients with MDS and 194 AML for 6 and a half years for treatment response and survival. 90 cases of MDS including 63 males and 27 females, aged 17-98 years old. The median age was 64 years and 11 patients were under 50 years of age. A total of 194 AML males, 122 females, 72 women aged 16-94 years, the median age of 50 years. There were 66 cases (73%) of chromosomal abnormalities in MDS and 24 cases of normal chromosomes. Divided into eight chromosome types: a simple 5q deletion; -7 or 7q deletion; +8; 20q deletion; a mixed defect; two mixed defects; complex defects and normal chromosomes. Chromosome normal and 5q deletion (mainly RA) prognosis is good, two groups of 31 patients with 29 cases of median follow-up was 18 months, 12 patients were followed up for more than 3 years. There were only 2 cases of triploid 8, 7q deletion / -7 or 37 cases with complex defects,