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目的探讨传染性单核细胞增多症以及langerhans细胞组织细胞增生症的临床表现和诊治方法。方法对诊治的1例传染性单核细胞增多症合并langerhans细胞组织细胞增生症患者进行病例分析和相关文献复习。结果患者为17岁男性,因“咽痛发热10d,皮疹2d”收入院。经头孢美唑钠、亚胺培南西司他丁钠、替考拉宁、利奈唑胺、头胞哌酮舒巴坦抗细菌及利巴韦林、更昔洛韦抗病毒治疗后无效,经骨髓细胞学检测确诊为传染性单核细胞增多症,经淋巴结病理学检查确诊为langerhans细胞组织细胞增生症,经COP化疗1疗程后体温正常。后经5疗程COP方案巩固治疗。结论传染性单核细胞增多症同时合并langerhans细胞组织细胞增生症极为罕见,经COP方案治疗效果较好。
Objective To investigate the clinical manifestations and diagnosis and treatment of infectious mononucleosis and langerhans cell histiocytosis. Methods One case of infectious mononucleosis diagnosed and treated with langerhans cell histiocytosis patients were analyzed and related literature review. Results The patient was 17-year-old male, because “sore throat fever 10d, rash 2d ” income hospital. Cefmetazole sodium, imipenem cilastatin sodium, teicoplanin, linezolid, siphonipamide sulbactam antibacterial and ribavirin, ganciclovir antiviral therapy after the invalid Bone marrow cytology was diagnosed as infectious mononucleosis syndrome, diagnosed by lymph node pathology langerhans cell histiocytosis, COP treatment of 1 course of normal body temperature. After 5 courses of COP treatment to consolidate the treatment. Conclusion Infectious mononucleosis combined with langerhans cell histiocytosis is extremely rare, the COP effect of treatment is better.