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目的探讨超敏C-反应蛋白(hs-CRP)、血脂在女性更年期综合征中的临床应用价值。方法测定90例更年期综合征妇女(其中排除合并其他病症者52例为观察组I;合并心脑血管疾病者38例为观察组II)和43例健康妇女(对照组)的hs-CRP及血脂,并做比较分析。结果观察组I与对照组相比,总胆固醇(TC)、甘油三酯(TG)明显升高,差异有统计学意义(P<0.05),hs-CRP、低密度脂蛋白胆固醇(LDL-C)升高,高密度脂蛋白胆固醇(HDL-C)降低,但差异无统计学意义(P>0.05);观察组II与对照组相比,hs-CRP、TC、TG、LDL-C明显升高,HDL-C明显降低,差异有统计学意义(P<0.05);观察组II与观察组I相比,hs-CRP、TC、TG、LDL-C明显升高,HDL-C明显降低,差异有统计学意义(P<0.05)。hs-CRP与TC、TG、LDL-C呈正相关(P<0.05),与HDL-C成负相关(P<0.05)。结论单纯更年期综合征患者存在血脂异常及hs-CRP开始增高,更年期综合征合并心脑血管疾病者血脂及hs-CRP明显异常,炎症可能参与了更年期综合征的进展,hs-CRP、血脂是预测未来风险的良好指标。
Objective To investigate the clinical value of high sensitivity C-reactive protein (hs-CRP) and lipids in women with menopausal syndrome. Methods The serum levels of hs-CRP and lipids in 90 cases of climacteric syndrome women (exclusion of 52 cases with other diseases were observed group I; 38 cases of cardiovascular and cerebrovascular diseases as observation group II) and 43 healthy women (control group) , And make comparative analysis. Results Compared with the control group, total cholesterol (TC) and triglyceride (TG) in observation group I were significantly increased (P <0.05), hs-CRP and LDL-C (P> 0.05). Compared with the control group, hs-CRP, TC, TG and LDL-C in observation group II were significantly increased (P <0.05). Compared with the observation group I, hs-CRP, TC, TG and LDL-C in observation group II were significantly increased and HDL-C was significantly decreased The difference was statistically significant (P <0.05). There was a positive correlation between hs-CRP and TC, TG and LDL-C (P <0.05), but negatively correlated with HDL-C (P <0.05). Conclusions Dyslipidemia and hs-CRP in patients with simple climacteric syndrome may be increased. Serum lipids and hs-CRP may be significantly abnormal in menopausal syndrome with cardiovascular and cerebrovascular diseases. Inflammation may be involved in the progression of menopausal syndrome. Hs-CRP and blood lipids are predicted Good indicator of future risk.