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目的观察血流储备分数(fractional flow reserve,FFR)指导下介入治疗冠脉临界病变对非ST段抬高型急性冠脉综合征(NSTE-ACS)患者短期预后的影响。方法选取西京医院心血管内科冠状动脉造影(CAG)确定单支冠脉狭窄程度为50%~70%且拟行经皮冠状动脉介入(PCI)治疗的192例NSTE-ACS患者为研究对象,按随机数字表将患者分为CAG组(n=96)和FFR组(n=96),患者随访12个月,比较两组患者再发心绞痛和主要不良心血管事件(MACE)的发生情况。结果与CAG组比较,FFR组再发心绞痛和MACE事件发生率均显著降低(P<0.05)。结论 FFR指导下PCI治疗冠脉临界病变可更显著降低术后1年MACE事件发生率。
Objective To observe the effect of interventional treatment of critical coronary lesion on the short-term prognosis of patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) guided by fractional flow reserve (FFR). Methods A total of 192 patients with NSTE-ACS who underwent percutaneous coronary intervention (PCI) were enrolled in this study. They were randomized to receive coronary angiography (CAG) at Xijing Hospital to determine the degree of stenosis of single coronary artery in 50% -70% The patients were followed up for 12 months in the CAG group (n = 96) and the FFR group (n = 96). The incidence of recurrent angina and major adverse cardiac events (MACE) was compared between the two groups. Results Compared with CAG group, the incidence of recurrent angina pectoris and MACE in FFR group was significantly lower (P <0.05). Conclusion FFR-guided PCI can significantly reduce the incidence of MACE at 1 year after PCI.