论文部分内容阅读
目的 探讨原发性开角型青光眼 (POAG)发病的危险因素。方法 调查两组不同类型的人群资料 ,采用logistic回归分析法探索POAG的危险因素。第一组资料由 1995～ 2 0 0 0年的 10 7例POAG住院患者组成病例组 ,由同期住院的 14 9例非POAG患者组成对照组。第二组资料由 2 0 0 0年 3～ 12月就诊的 4 0例POAG患者作为病例组 ,由同期就诊的 12 0例非POAG患者组成对照组。前者采用成组病例对照研究设计 ,后者采用 1∶3匹配病例对照研究设计。对年龄、性别、家族史、糖尿病、高血压、眼压、心血管病、吸烟、饮酒和TIGR基因突变等因素与POAG发病危险性的关系进行研究。结果 单因素分析提示年龄、家族史、高血压、眼压、心血管病、吸烟、饮酒和TIGR基因突变(T35 3I)等因素与POAG发病有关。logistic回归分析进一步表明 :眼压、家族史、高血压、吸烟、饮酒和TIGR基因突变 (T35 3I)与POAG关系密切。结论 国人POAG发病的最主要危险因素是眼压 ,其次是家族史、高血压、吸烟和TIGR基因突变 (T35 3I) ,而饮酒则是POAG的保护因素
Objective To investigate the risk factors of primary open angle glaucoma (POAG). Methods The data of two groups of different types of people were investigated. The risk factors of POAG were explored by logistic regression analysis. The first group consisted of 107 POAG inpatients from 1995 to 2000, which consisted of 149 non-POAG patients hospitalized in the same period. The second group consisted of 40 POAG patients treated from March to December in 2000 as the case group. The control group consisted of 120 POAG patients treated at the same period. The former uses a group case-control study design, which uses a 1: 3 matched case-control study design. The relationship between age, gender, family history, diabetes mellitus, hypertension, intraocular pressure, cardiovascular disease, smoking, alcohol consumption, TIGR gene mutation and the risk of POAG were studied. Results Univariate analysis suggested that age, family history, hypertension, intraocular pressure, cardiovascular disease, smoking, alcohol consumption and T353I mutations were associated with the pathogenesis of POAG. Logistic regression analysis further showed that intraocular pressure, family history, hypertension, smoking, alcohol consumption and TIG3 gene mutation (T35 3I) were closely related to POAG. Conclusions The most important risk factors for POAG in our country are intraocular pressure (IOP), followed by family history, hypertension, smoking and TIG3 gene mutation (T35 3I), while alcohol consumption is the protective factor of POAG