In the dorsal raphe neucleus,the role of Ca2+,PKC and CaMKⅡ in sleep-wake regulation

• 作 者: CUI Su-ying CUI Xiang-yu 张永鹤
• 机 构: DepartmentofPharmacology,北京大学基础医学院药理学系
• 出 处: 中国药理学与毒理学杂志
• 发表日期: 2017年5期
• 基金项目: The project supported by National Natural Science Foundation of China(81573407,81302746,81202511,81173031),National Mega-project of Scicence Research of China for New Drug Development(2009ZX09103-124)

OBJECTIVE Dorsal raphe nucleus（DRN） is the largest single collection of neurons containing5-HT in the entire brain and particularly attractive in a wide variety of complex physiological and behavioral processes,such as sleep-wake regulation. Calmodulin de