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目的:为了观察新生儿与小婴儿巨结肠平滑肌病理改变,方法:对15例新生儿和小婴儿巨结肠手术标本进行病理组织学与抗肌动蛋白免疫组化观察。结果:见平滑肌层网状纤维密度增加、PAS 环变形、平滑肌嗜酸性变、肌动蛋白减少或消失等变化由近至远段依次加重、与神经节细胞分布有关。结论:本病肌层病变具有一定特征,对临床有实用价值。
Objective: To observe the histopathology and anti-actin immunohistochemistry of Hirschsprung’s smooth muscle in neonates and infants. Methods: Fifteen neonates and infants with giant colon surgery specimens were observed histopathologically and anti-actin immunohistochemically. Results: The changes of the density of reticular fibers in the smooth muscle layer, the deformation of the PAS ring, the eosinophilic changes of smooth muscle and the decrease or disappearance of actin increased from near to far in turn, which were related to the distribution of ganglion cells. Conclusion: The myopathy of the disease has certain characteristics, which have clinical value.