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目的探讨幽门螺杆菌(Hp)、一氧化氮(NO)、肥大细胞(MC)及其脱颗粒在功能性消化不良(FD)各亚型发病中的作用。方法按罗马Ⅱ标准选择FD患者35例,取胃窦黏膜若干,行快速尿素酶试验(RUT)、HE染色、14C尿素呼气试验检测Hp;硝酸还原酶比色法测定NO含量;免疫组化法测MC数及其脱颗粒数。结果(1)FD各型间Hp感染率、NO、MC及其脱颗粒数无明显差异。(2)在FD患者,MC与NO呈负相关(r=-0.367,P=0.030<0.05)。结论(1)FD各分型与各指标没有明显关系。(2)FD患者中MC数与NO含量呈负相关,在FD发病中可能有一定意义。
Objective To investigate the role of Helicobacter pylori (Hp), nitric oxide (NO), mast cells (MCs) and their degranulation in the pathogenesis of functional subtypes of dyspepsia (FD). Methods 35 patients with FD were selected according to the criteria of Rome Ⅱ. Several gastric mucosa of gastric antrum were selected. The rapid urease test (RUT), HE staining and 14C urea breath test were used to detect Hp. Nitric acid reductase colorimetry was used to determine the content of NO. Method to measure the number of MC and degranulation. Results (1) There was no significant difference in Hp infection rate, NO, MC and the number of degranulation among the various types of FD. (2) There was a negative correlation between MC and NO in FD patients (r = -0.367, P = 0.030 <0.05). Conclusion (1) There is no obvious relationship between the various types of FD and each index. (2) There was a negative correlation between the number of MC and NO in FD patients, which may have some significance in the pathogenesis of FD.